Rheumatology‎ > ‎

Seronegative Arthritis

Spondyloarthopathies
  • Current classification 
    • Axial Spondyloarthritis
      • With radiographic sacroileitis
      • Without radiographic sacroiletis 
        • MRI positive 
        • HLA B27 positive 
    • Peripheral sondyloarthritis 
      • With Psoriasis 
      • With IBD
      • With preceding infection
      • Without IBD, Psoriasis, or Preceding infection 
  • 4 Major Groups (classic classification) 
    1. Reactive Arthritis 
    2. Ankylosing Spondylitis 
    3. Psoriatic Arthritis 
    4. Enteropathic Arthritis (IBD associated)

Common C/F
  • Both Axial or Peripheral Arthritis can occur
  • Enthesitis
  • Dactylitis


1. Reactive Arthritis 
  • Skin Manifestations: 
    • Keratoderma Blenorrhagica


2. Ankylosing Spondylitis 


3. Psoriatic Arthritis 
  • Pathogenesis: 



4. Enteropathic Arthritis (IBD associated)


Clinical Trials on 

Psoriatic arthritis
  • ACR20
  • ACR50
  • ACR70
  • Health Assessment Questionnaire Disability Index (HAQ-DI
Ankylosing Spondylitis 
  • Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), 
  • Functional ability measured by the Bath Ankylosing Spondylitis Functional Index (BASFI), and 
  • mobility of the spine measured by the Bath Ankylosing Spondylitis Metrology Index (BASMI)
  • Assessment in Ankylosing Spondylitis (ASAS) criteria 
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