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SLE Clinical Manifestation



  • Arthritis and arthralgias
    • occur in over 90 percent of patients with SLE and are often one of the earliest manifestations
    • Arthritis, with demonstrable inflammation, occurs in 65 to 70 percent of patients and tends to be migratory, polyarticular, and symmetrical
  • Cutaneous Lupus (Lupus Specific or Lupus Non-specific
    • Lupus Specific )
      • Acute cutaneous lupus erythematosus (ACLE)

        Localized ACLE (ie, malar rash, butterfly rash)

        Generalized ACLE

        Toxic epidermal necrolysis-like ACLE

        Subacute cutaneous lupus erythematosus (SCLE)

        Annular SCLE

        Papulosquamous SCLE

        Drug-induced SCLE

        Less common variants: erythrodermic, poikilodermatous, erythema multiforme-like (Rowell syndrome), and vesiculobullous annular SCLE

        Chronic cutaneous lupus erythematosus (CCLE)

        •Discoid lupus erythematosus (DLE)

        -Localized DLE

        -Generalized DLE

        -Hypertrophic DLE

      • 15 to 30 percent

      •  DLE have increased risk for photosensitivity and leukopenia but decreased risk for serositis and arthritis

        •Lupus erythematosus tumidus (LE tumidus)

        •Lupus profundus (also known as lupus panniculitis)

        •Chilblain lupus erythematosus (chilblain LE)

        •Lichenoid cutaneous lupus erythematosus-lichen planus overlap syndrome (LE-LP overlap syndrome)

  • NPSLE Ref: Neurological Manifestations of Systemic Lupus Erythematosus in Children and Adults 2010
    • 12 Central Nervous System7 Peripheral Nervous System
      1. Aseptic meningitis

      2. Cerebrovascular disease

      3. Demyelinating syndrome

      4. Headache

      5. Movement disorder

      6. Myelopathy

      7. Seizure

      8. Acute confusional state

      9. Anxiety disorder

      10. Cognitive dysfunction

      11. Mood disorder

      12. Psychosis

      1. Guillain-Barré syndrome

      2. Autonomic disorder

      3. Mononeuropathy, single/multiplex

      4. Myasthenia gravis

      5. Cranial neuropathy

      6. Plexopathy

      7. Polyneuropathy


  • Pulmonary Manifestation
    1. Pleuritis
    2. Plerual effusion
    3. DAH
    4. Acute Pneumonitis
    5. CILD 
    6. PAH
    7. Shrinking Lung Syndrome
    8. Small airway disease 
    9. BOOP (rare case reports)






11 Clinical Criteria and 6 Immunological Criteria
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