Overlap Syndrome/MCTD

MCTD Includes SLE Polymyositis Systemic Sclerosis  RA high titer of anti-U1-ribonucleoprotein (RNP) antibodies SLE patients can have anti-U1 RNP ab. This does not mean it is a MCTD by default  In contrast to SSc, MCTD often responds to glucocorticoids, and the long-term prognosis is better than that of SSc. Whether MCTD is truly a distinct entity or is a subset of SLE or SSc, remains controversial. Clinical Features Similar to each component of Diseases Arthritis is usually non-erosive however, RA like erosive arthritis can occur “To Be or Not To Be,” 10 yrs After: Evidence for MCTD as a Distinct Entity Seminars in Arthr and Rheum 2012 “To Be or Not To Be,” 10 yrs After: Evidence for MCTD as a Distinct Entity Seminars in Arthr and Rheum 2012 “To Be or Not To Be,” 10 yrs After: Evidence for MCTD as a Distinct Entity Seminars in Arthr and Rheum 2012 “To Be or Not To Be,” 10 yrs After: Evidence for MCTD as a Distinct Entity Seminars in Arthr and Rheum 2012