Rheumatology‎ > ‎

Overlap Syndrome/MCTD

  • SLE
  • Polymyositis
  • Systemic Sclerosis 
  • RA
  • high titer of anti-U1-ribonucleoprotein (RNP) antibodies
    • SLE patients can have anti-U1 RNP ab. This does not mean it is a MCTD by default
  •  In contrast to SSc, MCTD often responds to glucocorticoids, and the long-term prognosis is better than that of SSc. Whether MCTD is truly a distinct entity or is a subset of SLE or SSc, remains controversial.

Clinical Features
  • Similar to each component of Diseases
  • Arthritis is usually non-erosive however, RA like erosive arthritis can occur