- RESTLESS LEG SYNDROME: Primary (or Idiopathic; 40% have family history ) vs. Secondary (Iron deficiency, ESRD, DM, MS, PD, Pregnancy, Rheumatic Disease, Venous Insufficiency, Drugs
- PLMD (Periodic Leg Movement Disorder; PLMS - Sleep; PLMW - Wakefulness) may be associated but are not RLS and do not require treatment
- Dx: URGE
- Uncomfortable urge to move legs
- Rest occurrence / worsening
- Getting up releives
- Evening Predominance
- DDx: Peripheral Neuropathy, Lumbosacral radiculopathy, Nucturnal Leg Cramps. Need to differentiate from Akathisia (generalized inner restlessness)
- Treatment: Dopaminergic agonists (S.E: N, Dizziness, ICD)
- Augmentation: Tolerance, Overall worse symptoms, Spread to UE, Need of drug earlier in the day; can be treated with alpha-3-delta drugs (gabapentin / pregablin) or an opiate is usually necessary
- References
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