Infectious Disease‎ > ‎HIV‎ > ‎


HIV-IRIS (Immune Reconstitution Inflammatory Syndrome) (Ref: Cecil Text Book)

Dissemenated MAC (IRIS) :Fever, Chills, Sweats, Fatigue, Weight Loss
  • Sx: Abdominal pain, N, V
  • Signs: Diffuse Lymhadenopathy, Hepatomegaly, Splenomegaly, 
  • Imaging: Retroperitoneal Lymphadenopathy 
  • Rx: Macrolide based Multidrug regiment, usually clarithromycin and ethambutal
CMV IRIS (Retinitis, Hepatitis, Colitis, Esophagitis)
  • Sx: Visual Sx
  • Signs: Cytopenias, Hepatits, Retinitis
Candida: Usually does not cause disseminated cardidal infection in AIDS, but rather a mucocutaneous infection 
  • Hence, neither disseminated infection nor systemic symptoms of candida occur in HIV 
Cryptococcal IRIS
  • CNS IRIS: intracranial cryptococcoma or abscesses, spinal cord abscesses, recalcitrant raised intracranial pressure, optic disc swelling, cranial nerve lesions, dysarthria, hemiparesis, and paraparesis. 
  • Extra-CNS IRIS: lymphadenitis, eye disease, suppurating soft tissue lesions, and pulmonary disease that may include cavitating or nodular lesions.