HIV and GI / Pulm / Nephro

HIV-GI

Etiologies
Opportunistic Infection:
Bacterial: MAC
Viral: CMV,
Parasitic: Crytosporodiosis
Fungal: Localised candidal infection (Oral candida infection typically occur when CD4 < 200, but if additional risk factors like inhaled steroids exists, can occur at CD4 > 200.
IRIS due to above infection
Medication Side Effects
Abacavir (usually shortly after therapy initiation)
Current Concepts: Viral Hepatitis in HIV Infection NEJM
Case 2-2006: A 31-Year-Old, HIV-Positive Man with Rectal Pain (DDx of Proctitis)

HIV-GI - Hepatobiliary

Crytosporodiosis

HIV-Pulmonary Medicine

PCP Pneumonia

https://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf B2)

https://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf B8)

https://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf B9)

Case 31-2013: A 29-Year-Old Man with Abdominal Pain, Fever, and Weight Loss (CD4 10; Disseminated Histoplasm)
Case 18-2009: A 24-Year-Old Woman with AIDS and Tuberculosis with Progressive Cough, Dyspnea, and Wasting (Extensively Drug Resistant TB)

HIV-Nephro

Etiologies

Opportunistic Infection:

Bacterial:
Viral: HIVAN (Collapsing FSGS), HBV associated Nephropathy
Parasitic:
Fungal:

IRIS due to above infection
Medication Side Effects

Cobicistat: inhibits Cr secretion causing Cr to go high, but does not alter the GFR. If > 0.4 mg / dL increase in Cr then cause of elevation in Cr should be looked into
Tenofovir Renal Toxicity