Staph Infection

STAPH. AUREUS BACTEREMIA, MSSA or MRSA: Source-      ; MIC-      ; Clinical Improvement / Stable / Worsening - Search for source if unclear, 2D ECHO; Treatment plan -     ; Remove source of Infection; Repeat cultures in 3-4 days; Need of PICC line. 
Clinical Management of Staphylococcus aureus Bacteremia A Review JAMA 2014

Case based learning 
Case 1 
82 yo gentleman with DM, venous stasis, PAD, and chronic skin infection and chronic non-healing ulcer has a superficial wound culture done. It grows Coagulase positive Staph with following sensitivity. What do you do with this information. Because it is a superficial wound culture can you disregard the concern for gram negative, and anaerobic infection on this gentleman? 



Antibiotic

MIC

Sensitivity


Cefazolin

>16

Resistant


Clindamycin

>4

Resistant


Erythromycin

>4

Resistant


Gentamicin

<1

Susceptible


Oxacillin

>2

Resistant


Penicillin

>8

Resistant


Tetracycline

<1

Susceptible


Trimethoprim/Sulfa

<0.5/9.5

Susceptible


Vancomycin

1

Susceptible


Answer: Section V of CID 2012


2012 IDSA Clinical Practice Guideline for the Diagnosis and Treatment of DFI CID 2012


Staph UTI 
50 yo F with multiple co-mobidities has symptoms of UTI. Urine culture grows the following. 

Staph aureus : 50,000-100,000 colony forming units per mL

ANTIMICROBIAL SUSCEPTIBILITY 

Comments: S = Susceptible; I = Intermediate; R = Resistant 
P = Positive; N = Negative
MICS are expressed in micrograms per mL
Ciprofloxacin S =1
Gentamicin S<=0.5
Levofloxacin S =0.5
Linezolid S =4
Nitrofurantoin S =32
Oxacillin R>=4
Penicillin R>=0.5
Rifampin S<=0.5
Tetracycline S<=1
Trimethoprim/Sulfa S<=10
Vancomycin S =1

How do you manage this patient? 


30 y/o F presents with symptoms of UTI. Patient has stents placed in the bilateral ureters. 

Urine Culture is performed and show Coagulase negative Staphylococcus species, not Staphylococcus saprophytic us. 25,000-50,000 colony forming units per mL

Comments:  S = Susceptible; I = Intermediate; R = Resistant 
P = Positive; N = Negative
MICS are expressed in micrograms per mL
Ciprofloxacin R>=8
Gentamicin S<=0.5
Levofloxacin R>=8
Nitrofurantoin S<=16
Oxacillin R>=4
Penicillin R>=0.5
Rifampin S<=0.5
Tetracycline S<=1
Trimethoprim/Sulfa S<=10
Vancomycin S<=0.5

How do you manage this patient? 

Additional references (Harrison's)

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