Appreciate the Role of Immune System in Various Renal Diseases A Brief Journey through the Immune System CJSAN 2015
Case 3-2014: A 61-Year-Old Woman with Gastrointestinal Symptoms, Anemia, and Acute Kidney Injury (RPGN):
Causes of RPGN- a) Anti - GBM
- b) ANCA Vasculitis
- c) Immune complex disease
- Low Complement Immune Complex Disease
- Alternate Pathway (Normal C4, Depressed C3; decreased Factor B)
- Usually uncommon in clinical medicine
- Pediatric renal diseases MPGN, C3 Glomerulopathies,
- IgG 2 and IgG 4 do not activate classic pathways, and upon binding to protein can activate alternate pathway. This can sometime happen in SLE
- Also involved during or by Dialysis, some microbes,
- aHUS
- Classic Pathway (Depressed C4, Normal or Low C3)
- Cryoglobulinemia
- SLE
- Post-streptococcus GN
- Endocarditis
- MPGN
- Normal Complement Immune Complex Diseases
- Ig A Nephropathy IgA Nephropathy NEJM 2013
- HSP (Henoch-Scholein Purpura)
- Fibrillary GN (Polyclonal Gammopathy), Immunotactoid GN (Monoclonal Gammopathy)
- Lytic phase
Case 23-2009: A 13-Y-O Boy with Headache, Nausea, Seizures, and HTN (Atypical Hemolytic syndrome) - Alternate Pathway:
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