WHO classification of tumors of hematopoietic and lymphoid tissues

(The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications Blood 2011)

  1. Mature B-Cell Neoplasms
  1. B-cell prolymphocytic Leukemia
  2. Mantle  Cell Lymphoma
  3. Diffuse Large B Cell Lymphoma and its variants Blood 2011
  4. CLL / SLL
    1. Follicular / Burkitt's
    2. Heavy Chain Disease
    3. Multiple Myeloma and its spectrum of diseases 
  1. Mature T-Cell and NK-Cell Neoplasms
Pathway of normal T-cell differentiation and relationship to T-cell lymphomas Harrison's Principles of Internal Medicine, 19e
  1. Hodgkin Lymphoma
  2. Histiocytic and dendritic cell neoplasms
  3. Pasttransplantation lymphoproliferative disorders (PTLDs)
NHL : 5 most common type of NHL are:
  • Most common is DiFFuse 
  • DiFFuse -- Next common will be from F
  • FoLLicular -- Next common will be from M, near L and has L
  • MALt -- next one is from M but is T cell
  • Mature T cell 
Lumbar Puncture: Indicated for most aggressive NHL involving 
  • Sinuses
  • Testes
  • Bone Marrow
  • Ocular Sites
Classification based on prognosis
  • Indolent
    • Incurable, but prolonged progression free survival (7-10 yrs)
    • Follicular, MALT, CLL, Hairy Cell
  • Aggressive
  • Highly aggressive
    • Later two are curable, but short progression free survival
    • Later two includes
      • Diffuse Large B Cell
      • Mantle 
      • HD
      • Cutaneous T Cell - NHL
NHL Lancet 2013
HD Lancet 2013
Common misdiagnoses in lymphomas and avoidance strategies Lancet 2010
Burkitt's lymphoma Lancet 2012

How I treat primary CNS lymphoma Blood 2011
Anti-CD20 Antibody Therapy for B-Cell Lymphomas NEJM 2012
The Pathogenesis of Mycosis Fungoides NEJM 2004
How I treat HIV-associated lymphoma Blood 2012 
Bilateral Lower Palpebral MALT Lymphoma NEJM (Image)