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Hematological Neoplasms


Stem Cells and Their Disorders

Lymphadenopathy and Lymphoid Malignancies

Case 40-2014: Lymphadenopathy, and HIV Infection
Case 38-2013:  Fever and Lymphadenopathy
Case 27-2009 Fever and Rash 
Case 30-2005 Fever and Axillary Lymphadenopathy
AIDS-related lymphoproliferative disease Blood 2006

Leukemia: An Overview for Primary Care AAFP 2014 (Mercer Only)
Leukaemia update. Part 1: diagnosis and management BMJ 2013
Leukaemia update. Part 2: managing patients with leukemia in the community BMJ 2013
How I treat the peripheral T-cell lymphomas Blood 2013
ALL Lancet 2013
Treatment of Acute Lymphoblastic Leukemia NEJM 2006
Chronic myeloid leukaemia Lancet 2007

Lymphoma and Leukemia
Glucocorticoid use in acute lymphoblastic leukemia Lancet 2010

WHO classification of myeloid neoplasms and acute leukemia 
(The 2008 revision of the WHO classification of myeloid neoplasms and acute leukemia Blood 2009)

1. Myeloproliferative neoplasms (MPN)

  1. Chronic myelogenous leukemia, BCR-ABL1–positive (CML)
  2. Chronic neutrophilic leukemia (CNL)
  3. Polycythemia vera
  4. Primary myelofibrosis
  5. Essential thrombocythemia
  6. Chronic eosinophilic leukemia, not otherwise specified (CEL)
  7. Mastocytosis
  8. Myeloproliferative neoplasms, unclassifiable

2. Myeloid and lymphoid neoplasms associated with eosinophilia and abnormalities of PDGFRAPDGFRB, or FGFR1

  1. Myeloid and lymphoid neoplasms associated with PDGFRA rearrangement Myeloid neoplasms associated with PDGFRB rearrangement
  2. Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities

3. Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

  1. Chronic myelomonocytic leukemia
  2. Atypical chronic myeloid leukemia, BCR-ABL1–negative Juvenile myelomonocytic leukemia Myelodysplastic/myeloproliferative neoplasm, unclassifiable
  3. Provisional entity: refractory anemia with ring sideroblasts and thrombocytosis

4. Myelodysplastic syndrome (MDS)

  1. Refractory cytopenia with unilineage dysplasia Refractory anemia
  2. Refractory neutropenia
  3. Refractory thrombocytopenia
  4. Refractory anemia with ring sideroblasts 
  5. Refractory cytopenia with multilineage dysplasia 
  6. Refractory anemia with excess blasts 
  7. Myelodysplastic syndrome with isolated del(5q) 
  8. Myelodysplastic syndrome, unclassifiable 
  9. Childhood myelodysplastic syndrome
  10. Provisional entity: refractory cytopenia of childhood

5. Acute myeloid leukemia and related neoplasms

  1. Acute myeloid leukemia with recurrent genetic abnormalities
    • AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
    • AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 APL with t(15;17)(q22;q12); PML-RARA
    • AML with t(9;11)(p22;q23); MLLT3-MLL
    • AML with t(6;9)(p23;q34); DEK-NUP214
    • AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1
    • AML (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1 Provisional entity: AML with mutated NPM1
    • Provisional entity: AML with mutated CEBPA
  2. Acute myeloid leukemia with myelodysplasia-related changes 
  3. Therapy-related myeloid neoplasms
  4. Acute myeloid leukemia, not otherwise specified
    • AML with minimal differentiation
    • AML without maturation
    • AML with maturation
    • Acute myelomonocytic leukemia
    • Acute monoblastic/monocytic leukemia Acute erythroid leukemia
      • Pure erythroid leukemia
      • Erythroleukemia, erythroid/myeloid 
    • Acute megakaryoblastic leukemia 
    • Acute basophilic leukemia
    • Acute panmyelosis with myelofibrosis
  5. Myeloid sarcoma
  6. Myeloid proliferations related to Down syndrome
    • Transient abnormal myelopoiesis
    • Myeloid leukemia associated with Down syndrome 
  7. Blastic plasmacytoid dendritic cell neoplasm

6. Acute leukemias of ambiguous lineage

  1. Acute undifferentiated leukemia
  2. Mixed phenotype acute leukemia with t(9;22)(q34;q11.2); BCR-ABL1 Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged
  3. Mixed phenotype acute leukemia, B-myeloid, NOS
  4. Mixed phenotype acute leukemia, T-myeloid, NOS
  5. Provisional entity: natural killer (NKcell lymphoblastic leukemia/lymphoma

7. B lymphoblastic leukemia/lymphoma

  1. B lymphoblastic leukemia/lymphoma, NOS
  2. B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
  • B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2);BCR-ABL 1 B lymphoblastic leukemia/lymphoma with t(v;11q23);MLL rearranged
  • B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22) TEL-AML1
  • (ETV6-RUNX1)
  • B lymphoblastic leukemia/lymphoma with hyperdiploidy
  • B lymphoblastic leukemia/lymphoma with hypodiploidy
  • B lymphoblastic leukemia/lymphoma with t(5;14)(q31;q32) IL3-IGH
  • B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1

8. T lymphoblastic leukemia/lymphoma 

HD: Lancet 2012; 380: 836–47 
Lancet 2012; 380: 836–47 
Lancet 2012; 380: 836–47 
Lancet 2012; 380: 836–47 

Lancet 2012; 380: 836–47