WHO classification of myeloid neoplasms and acute leukemia 
(The 2008 revision of the WHO classification of myeloid neoplasms and acute leukemia Blood 2009)

1. Myeloproliferative neoplasms (MPN)

1. Chronic myelogenous leukemia, BCR-ABL1–positive (CML)
2. Chronic neutrophilic leukemia (CNL)
3. Polycythemia vera
4. Primary myelofibrosis
5. Essential thrombocythemia
6. Chronic eosinophilic leukemia, not otherwise specified (CEL)
7. Mastocytosis
8. Myeloproliferative neoplasms, unclassifiable

2. Myeloid and lymphoid neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1

1. Myeloid and lymphoid neoplasms associated with PDGFRA rearrangement Myeloid neoplasms associated with PDGFRB rearrangement
2. Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities

3. Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

1. Chronic myelomonocytic leukemia
2. Atypical chronic myeloid leukemia, BCR-ABL1–negative Juvenile myelomonocytic leukemia Myelodysplastic/myeloproliferative neoplasm, unclassifiable
3. Provisional entity: refractory anemia with ring sideroblasts and thrombocytosis

4. Myelodysplastic syndrome (MDS)

1. Refractory cytopenia with unilineage dysplasia Refractory anemia
2. Refractory neutropenia
3. Refractory thrombocytopenia
4. Refractory anemia with ring sideroblasts 
5. Refractory cytopenia with multilineage dysplasia 
6. Refractory anemia with excess blasts 
7. Myelodysplastic syndrome with isolated del(5q) 
8. Myelodysplastic syndrome, unclassifiable 
9. Childhood myelodysplastic syndrome
10. Provisional entity: refractory cytopenia of childhood

5. Acute myeloid leukemia and related neoplasms

1. Acute myeloid leukemia with recurrent genetic abnormalities
• AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
• AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 APL with t(15;17)(q22;q12); PML-RARA
• AML with t(9;11)(p22;q23); MLLT3-MLL
• AML with t(6;9)(p23;q34); DEK-NUP214
• AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1
• AML (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1 Provisional entity: AML with mutated NPM1
• Provisional entity: AML with mutated CEBPA
2. Acute myeloid leukemia with myelodysplasia-related changes 
3. Therapy-related myeloid neoplasms
4. Acute myeloid leukemia, not otherwise specified
• AML with minimal differentiation
• AML without maturation
• AML with maturation
• Acute myelomonocytic leukemia
• Acute monoblastic/monocytic leukemia Acute erythroid leukemia
• Pure erythroid leukemia
• Erythroleukemia, erythroid/myeloid 
• Acute megakaryoblastic leukemia 
• Acute basophilic leukemia
• Acute panmyelosis with myelofibrosis
5. Myeloid sarcoma
6. Myeloid proliferations related to Down syndrome
• Transient abnormal myelopoiesis
• Myeloid leukemia associated with Down syndrome 
7. Blastic plasmacytoid dendritic cell neoplasm

8. T lymphoblastic leukemia/lymphoma 

HD: Lancet 2012; 380: 836–47 

Lancet 2012; 380: 836–47 

Lancet 2012; 380: 836–47 

Lancet 2012; 380: 836–47 

Lancet 2012; 380: 836–47