DM1

Basal Insulin
  • Lantus (Glargine U-100):
    • onset of action: 2 hr 
    • 16-24 hr
    • 1 cc has 100 unit of Insulin
  • Levemir (BID dosing is preferred) 
  • Torijo (Glargine-U300)
    • onset of action: 6 hr 
    • 24 hr 
    • 1 cc has 300 unit of Insulin 
Intermediate acting Insulin 
  • NPH 
    • especially for pregnant DM patient
    • Protamine bound to regular human insulin (note: all others are insulin analogs) 
Prandial Insulin
  • Aspart
  • Lispro
  • Inhaled Insulin (is a regular Insulin)
  • Humalog U 200
  • Humain - R (Regular Insulin U 500) (elli lily) 
    • 1 cc has 500 units 
Premixed Insulin
  • 70/30 (70 basal / 30 prandial)
    • Humalin 70/30 (Regular Insulin 70 + 30 NPH) Elli Lily 
    • Novolin 70/30 (Regular Insulin 70 + 30 NPH) Another company Novartis
      • Thus, these above two are the same
    • Novolog 70/30 (Novolog-PH 70 with plain novolog 30) 
  • Humolog 75/25 (Humolgo-PH 75 with plain homolog 25) (Elli lily)
  • Humolgo 50 / 50 (Elli lily) 
 
Insulin Therapy in DM 
Goal:
  1. Avoid Hypoglycemia
    1. Start at lower dose for patient with 
      1. High risk for hypoglycemia i.e. CKD, AKI, Type 1, 
      2. Multiple comorbidities to avoid life threatening complications 
  2. Try to simulate physiological Insulin release 
    1. Pump is the best 
  3. Start low 








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