DKA / HHS / Hypoglycemia

  • Hypoglycemia
    • Rule of 15
      • If Glucose < 70 mg / dl : 15 gm of CHO
      • If < 50 : 30 gm of CHO
      • Acceptable CHO choices = 15 gm of CHO 
        • 4 glucose tab
        • 1/2 cup (4 oz) of juice or regular soda
        • 1 Tablespoon of sugar
      • Recheck in 15 min; retreat if <70 mg / dl
      • if > 70, and meal will not be provide in 30 min, give a snack of graham crackers / peanut butter or milk (slower acting CHO the will keep glucose at goal) 
      • If patient is unresponsive:
        • 1/2 - 1 amp of D50 % Or 
        • 1 mg of Glucagon 1 mg SC or IM, feed after waking up 

HYPOGLYCEMIA: Mostly in Renal Failure Patient / DM à insulin stacking / Sulphonylurea (avoid SSI; give low does basal and meal time)

Rapid overview for hypoglycemia in adults, other than significant sulfonylurea overdose Up-to-date
Causes of hypoglycemia in adults Up-To-Date 
Drugs other than anti hyperglycemic agents and alcohol reported to cause hypoglycemia Up-To-Date
Hypoglycemia: Interpretation of laboratory tests Up-To-Date 
Arterial calcium stimulation with hepatic venous sampling for insulinoma Up-To-Date
Nurse-initiated strategies for treating hypoglycemia JCEM 2013      

  • DKA
    • Low insulin
      • Fat: Lipolysis: FFA (goes to liver for Ketoacidosis, and Glycerol (goes to liver for gluconeogenesis)
      • Protein
      • Glucose: Hyperglycemia (usually > 250) 
        • If < 250, think of 
          • alcoholic ketoacidosis
          • starvation ketoacidosis
          • Partially treated DKA (insulin will drop glucose down quickly)
    • Ketoacids
      • Acetone
      • Acetoacetone
      • B - Hydroybutyrate
    • Treatment: Only REGULAR Insulin
      • Continue IV Insulin until
        • Acidosis is clear (ideally if no urine ketones, that is the end of the need of IV insulin) 
        • So, Monitor HCO3-, CO2, and Anion Gap
      • Potassium supplement can be started if good urine output, even if K 4 - 5. 
      • HCO3 : pH < 6.9, otherwise do not give. Given as a drip over 30 min (not as a bolus)
  • HHS
    • Osmolality > 320, Glucose > 600
    • Rapid drop in blood glucose will put them at risk of cerebral edema 
    • Ketone will be in trace (1+ in Urine)
  • References:







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