CVID







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All patient with CVID all get HRCT (CXR) will miss. (Refer to paper published in Blood) 

Pulmonary
  • GL-ILD
GI
  • Splenomegaly
Malignancy 
  • Lymphoma 
GLILD seen in patient with CVID has 3 various type of histopathology in a same patient. 
It is different from Sarcoidosis. Sarcoid nodule are smaller than that seen in GL-ILD. 
Normal PFT, and CXR does not rule out the presence of GL - ILD 

Nodular Lymphoid Hyperplasia If seen is suggestive of CVID 

IgA deficiency, and Autoimmunity

1/600 
Autoimmunity in upto 35 % 
23 % of group identified from healthy blood donor developed autoimmune disease over 20 years 

Autoimmune manifestation of coplement deficiency 
Majority will develop SLE 

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