Cirrhosis Liver: 2/2 (EtoH, AIH Type1 or Type 2, NAFLD, Wilsons, Hemochromatosis etc) 
 
 Understanding the pathophysiology in Cirrhosis Compensated vs Decompensated Disease   Appreciate the sequence of events that leads to Renal Failure in Cirrhosis Appreciate difference in decompensated stage in regards to "severity" of portal hypertension, and role of bacterial translocation causing "severe" splanchnic arterial vasodilatation Talking about the Bacterial Translocation (BT) causing decompensated cirrhosis, appreciate 3 layers of normal barriers for (BT) Appreciate how BT is a major player in decompensated state Coagulopathy in Cirrhosis How to assess the bleeding risk in patients with Cirrhosis? DVT prophylaxis in patient with Cirrhosis? Appreciate 3 steps of normal hemostasis steps, and pro- and Anti- hemostatic drivers in Cirrhosis Appreciate the impact of low ADAMTS 13 and high vWF despite low platelet counts Appreciate pro- and anti-coagulant mechanism Appreciate PT is not a proxy of such balance. It only reflects pro-hemostatic forces Note: INR was designed to monitor only the patients on vitamin K antagonists  Appreciate pro- and anti- fibrinolytic balance  Appreciate the balance of pro- and anti- hemostasis forces in cirrhosis and the narrow room of hemostasis Appreciate if PT / INR does not reflect the tendency to bleed, then what may be real factors  Appreciate the types of Renal Failure in Cirrhosis - 4 Main types Appreciate HRS - Type 1 and HRS - Type 2 Work up for Cirrhosis and Renal failure
Ascitis in Cirrhosis  Management of Cirrhosis and Ascites NEJM 2004
Causes of Portal HTN in the absence of Cirrhosis Appreciate the role of the following two steps in pathophysiology of portal hypertension
Appreciate the mechanism of Hepatic Firbogenesis  Best Practice & Research Clinical Gastroenterology 25 (2011) 195–206  
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